Home Antibody All anti-CLDN14 antibodies
Also for CLDN14 (NM_012130)
| Peptide with sequence C-SATHSGYRLNDYV, from the C Terminus of the protein sequence according to NP_036262; NP_652763.|
|Test: Human, Mouse. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
||ELISA: 1:128,000. WB: 1-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens claudin 14 (CLDN14), transcript variant epsilon|
Entrez Gene 23562 Human
Entrez Gene 56173 Mouse
Entrez Gene 304073 Rat
Entrez Gene 487751 Dog
|Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Two transcript variants encoding the same protein have been found for this gene. |
|TransmembraneDruggable Genome Cell adhesion molecules (CAMs)Tight junctionLeukocyte transendothelial migration|
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TA302811 (1µg/ml) staining of human liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.