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Anti-CHGA Antibody EP1030Y
Also for CHGA (NM_001275)
|A synthetic peptide corresponding to residues near the N-terminus of human Chromogranin A was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 10,000; IHC: 1: 100~250; ICC: 1: 100~250; FC: 1:20
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens chromogranin A (parathyroid secretory protein 1) (CHGA)|
|Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release (1). Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor ? (TNF?) induced gap formation in human umbilical venous endothelial cells (2). CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients (3). |
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Western blot - Chromogranin A antibody [EP1030Y]; Anti-Chromogranin A antibody [EP1030Y] + SH-SY5Y cell lysate at 10 µg.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 90 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Chromogranin A antibody [EP1030Y]; Human pancreas tissue stained with ab68271 at 1/100 dilution.