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Home Antibody All anti-CHGA antibodies

Anti-CHGA Antibody EP1031Y

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300723 Rabbit Monoclonal Antibody against CHGA (Clone EP1031Y) 100ul $325 In Stock
LC400511 CHGA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Chromogranin A was used as an immunogen.
Clone NameEP1031Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1: 1,000,000; IHC: 1:250-500; IP: 1:30
Predicted MW Explanation 51 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens chromogranin A (CHGA), transcript variant 1
Alternative NameCGA
Database LinkNP_001266
Entrez Gene 1113 Human
FunctionChromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release (1). Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells (2). CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients (3).
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Chromogranin A antibody [EP1031Y]; Anti-Chromogranin A antibody [EP1031Y] - Carboxyterminal end at 1/1000000 dilution + PC12 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 80-90 kDa .
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Other-Anti-Chromogranin A antibody [EP1031Y] - Carboxyterminal end(TA300723); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Paraffin-embedded sections) - Chromogranin A antibody [EP1031Y]; TA300723, at a 1/250 dilution, staining Human Chromogranin A in Pancreas using Immunohistochemistry, Paraffin Emebedded tissue.
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