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Anti-CHGA Antibody EP1031Y
Also for CHGA (NM_001275)
|A synthetic peptide corresponding to residues near the C-terminus of human Chromogranin A was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|WB, ASSAY, IHC
||WB: 1: 1,000,000; IHC: 1:250-500; IP: 1:30
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens chromogranin A (parathyroid secretory protein 1) (CHGA)|
|Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release (1). Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells (2). CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients (3). |
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Western blot - Chromogranin A antibody [EP1031Y]; Anti-Chromogranin A antibody [EP1031Y] - Carboxyterminal end at 1/1000000 dilution + PC12 cell lysate at 10 µg.Secondary.goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 80-90 kDa .
Other-Anti-Chromogranin A antibody [EP1031Y] - Carboxyterminal end(ab52983); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Paraffin-embedded sections) - Chromogranin A antibody [EP1031Y]; ab52983, at a 1/250 dilution, staining Human Chromogranin A in Pancreas using Immunohistochemistry, Paraffin Emebedded tissue.