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Home Antibody All anti-CHFR antibodies

Anti-CHFR Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302851
  • Goat Polyclonal Antibody against CHFR
100ug 325 3-7 Days
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IHC(1)

OriGene Data

Immunogen Peptide with sequence KFNHICEQTRFKN, from the C Terminus of the protein sequence according to NP_060693.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, PigCow Concentration0.5 mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:64,000. WB: 2.5µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (CHFR), transcript variant 4
Alternative NameRNF116; RNF196
Database LinkNP_060693
FunctionE3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons
Related Pathway

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IHC Image
TA302851 (2.5µg/ml) staining of paraffin embedded human brain (cerebellum). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

 

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