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Home All anti-CHEK2 antibodies
Anti-CHEK2 Antibody
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for CHEK2 (NM_001005735)
OriGene Data
| Chk2 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human Chk2 . |
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IgG |
| Human, Mouse, Rat |
1ug/ul |
| WB, IF |
ELISA, WB: 1 ug/ml, ICC: 1 ug/ml |
| PBS containing 0.02% sodium azide. |
| Affinity chromatography purified via peptide column (Protein A or G Sepharose) |
Reference Data
| Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3 |
| CDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53 |
| NP_001005735 |
| The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 (7,8). Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer (9). |
Cell cycle |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis of Chk2 expression in K562 (A), Jurkat (B), and HL-60 (C) whole cell lysates with Chk2 antibody at 1 ug /ml.
IF Image
Immunocytochemistry of Chk2 in Jurkat cells with Chk2 antibody at 1 ug/mL.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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