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Home Antibody All anti-CHEK2 antibodies

Anti-CHEK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306063
  • Rabbit Polyclonal Chk2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC423638) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for CHEK2 (NM_001005735)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenChk2 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human Chk2 .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3
Alternative NameCDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
Database LinkNP_001005735
Entrez Gene 11200 Human
Entrez Gene 50883 Mouse
Entrez Gene 114212 Rat
FunctionThe p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 (7,8). Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer (9).
Related PathwayProtein KinaseStem cell - PluripotencyDruggable Genome Cell cyclep53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Chk2 expression in K562 (A), Jurkat (B), and HL-60 (C) whole cell lysates with Chk2 antibody at 1 ug /ml.
IF Image
Immunocytochemistry of Chk2 in Jurkat cells with Chk2 antibody at 1 ug/mL.

 

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