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Home Antibody All anti-CFL2 antibodies

Anti-CFL2 Antibody

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SKU Description Amount Price Availability*  
TA302652
  • Goat Polyclonal Antibody against Cofilin 2 (muscle)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403364) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)

OriGene Data

Immunogen Peptide with sequence C-DIKDRSTLGEK, from the C Terminus of the protein sequence according to NP_068733.1; NP_619579.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human, Mouse, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:128,000. WB: 0.01-0.03µg/ml.
Predicted MW Explanation 18.6 kDa
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens cofilin 2 (muscle) (CFL2), transcript variant 2
Alternative NameNEM7
Database LinkNP_619579
Entrez Gene 1073 Human
Entrez Gene 12632 Mouse
Entrez Gene 366624 Rat
Entrez Gene 490649 Dog
FunctionCofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM].
Related PathwayDruggable Genome Axon guidanceFc gamma R-mediated phagocytosisRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

TA302652 (0.003µg/ml) staining of human muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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