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Home Antibody All anti-CDKN2B antibodies

Anti-CDKN2B TRUEMAB Antibody Clone OTI8H4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA505208 CDKN2B (p15 INK4b) mouse monoclonal antibody, clone OTI8H4 (formerly 8H4) 100ul $325 In Stock
LC417638 CDKN2B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505208 Carrier-free (BSA/glycerol-free) CDKN2B mouse monoclonal antibody, clone OTI8H4 (formerly 8H4) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(4)
IF(1)
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Also for CDKN2B (NM_004936)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human CDKN2B(NP_004927) produced in HEK293T cell.
Clone NameClone OTI8H4 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:500~2000, IHC 1:150, IF 1:100,
Predicted MW Explanation 14.5 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1
Alternative NameCDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Database LinkNP_004927
Entrez Gene 1030 Human
FunctionThis gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq].
Related PathwayDruggable Genome Cell cycleTGF-beta signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2B (RC204895, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2B.
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-CDKN2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505208)
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-CDKN2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505208)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-CDKN2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505208)
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Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-CDKN2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505208)
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Anti-CDKN2B mouse monoclonal antibody (TA505208) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDKN2B(RC204895).
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