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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A TRUEMAB Antibody Clone3H4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA802229
  • CDKN2A (p14ARF/p19ARF) mouse monoclonal antibody,clone 3H4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409229) , 20ug
100ul 325 In Stock
CF802229
  • Carrier-free (BSA/glycerol-free) CDKN2A mouse monoclonal antibody,clone 3H4
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
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Also for CDKN2A (NM_058195)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 25-156 of human CDKN2A (NP_478102) produced in E.coli.
Clone NameClone3H4 IsotypeIgG1
Species ReactivityHuman Concentration1.00 mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 4
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_478102
FunctionThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2A (RC211784, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2A.

 

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