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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A TRUEMAB Antibody Clone OTI8A1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA801873 CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI8A1 (formerly 8A1) 100ul 325
In Stock
LC400022 CDKN2A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF801873 Carrier-free (BSA/glycerol-free) CDKN2A mouse monoclonal antibody, clone OTI8A1 (formerly 8A1) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli.
Clone NameClone OTI8A1 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB 1:200 - 1:1000
Predicted MW Explanation 16.4 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
Entrez Gene 1029 Human
FunctionThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Related PathwayDruggable Genome Cell cyclep53 signaling pathwayPathways in cancerPancreatic cancerGliomaMelanomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2A (RC220937, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2A.

WB Image
Western blot analysis of extracts (10ug) from 2 different cell lines by using anti-CDKN2A monoclonal antibody at 1:200.

IF Image
Immunocytochemistry staining of MDA-MB-468 cells using anti-CDKN2A mouse monoclonal antibody (TA801873). The right is MCF7 cells as negative control. (1:100)


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