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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A TRUEMAB Antibody clone 4C11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500036
  • anti-CDKN2A (p16INK4a) mouse monoclonal antibody, clone 4C11
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400022) , 20ug Explanation
100ul
30ul
379 In Stock
CF500036
  • Carrier-free (BSA/glycerol-free) P16 mouse monoclonal antibody, clone 4C11
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
Add to Shopping Cart
WB(2)
IF(3)
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli.
Clone Nameclone 4C11 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB 1:1000, IF 1:100
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
Entrez Gene 1029 Human
FunctionP16 gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Related PathwayDruggable Genome Cell cyclep53 signaling pathwayPathways in cancerPancreatic cancerGliomaMelanomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY P16 (RC220937, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-P16.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-P16 monoclonal antibody.
IF Image
Anti-P16 mouse monoclonal antibody (TA500036) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY P16(RC220937).
IF Image
Immunofluorescent staining of HeLa cells using anti-P16 mouse monoclonal antibody (TA500036).
IF Image
Immunofluorescent staining of HepG2 cells using anti-P16 mouse monoclonal antibody (TA500036).

 

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