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Anti-CDC6 PHOSPHO Antibody EPR761(2)
Also for CDC6 (NM_001254)
|A phospho-specific peptide corresponding to residues surrounding Serine 106 of human Cdc6 was used as an immunogen. The antibody only detects Cdc6 phosphorylated on Serine 106.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens cell division cycle 6 (CDC6)|
|CDC18L; HsCDC18; HsCDC6|
|The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at origins of DNA replication during the G1 phase of the cell cycle (1). Cdc6 participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated (2). It has been concluded that expression of Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells (3). In vitro, Cdc6 is an excellent substrate for Cdk2, phosphorylated at three sites (Serine 54, Serine 74 and Serine 106) (4). |
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Western blot - Cdc6 (phospho S106) antibody [EPR761(2)]; All lanes : Anti-Cdc6 (phospho S106) antibody [EPR761(2)] at 1/2000 dilution.Lane 1 : Raji cell lysate.Lane 2 : Raji cell lysate treated with FBS.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 63 kDa.Observed band size : 63 kDa.