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Home Antibody All anti-CDC23 antibodies

Anti-CDC23 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319757
  • Rabbit Polyclonal APC8 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401477) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenAPC8 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC8.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml
BufferAPC8 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification APC8 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens cell division cycle 23 (CDC23)
Alternative NameANAPC8; APC8; CUT23
Database LinkNP_004652
Entrez Gene 8697 Human
Entrez Gene 52563 Mouse
Entrez Gene 291689 Rat
FunctionAPC8 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.
Related PathwayDruggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of APC8 in K562 cell lysate with APC8 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunocytochemistry of APC8 in K562 cells with APC8 antibody at 5 ug/mL.

 

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