Cluster of Differentiation 99 (CD99), also known as MIC2, is a T-cell surface glycoprotein involved in the T-cell adhesion process and spontaneous rosette formation with erythrocytes (1). It functions in the migration of leukocytes and the transport of ganglioside GM1 and transmembrane proteins (2). CD99 is also implicated in other cellular events such as thymocyte selection, apoptosis of neuronal cells, and T cell activation (3). Two isoforms of CD99 exist. The expression of the full-length long form (32 kDa) promotes cell adhesion, whereas the truncated short form (28 kDa) inhibits the process (3). The short-form isoform favors migration and metastasis of osteosarcoma, while the long-form version dramatically inhibits progression (3). Moreover, CD99 is used as an immunohistochemical marker for Ewing sarcoma and other neuroectodermal tumors (4).
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