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Home Antibody All anti-CD80 antibodies

Anti-CD80 Antibody EPR1157(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307243
  • Rabbit monoclonal antibody against B7-1/CD80(clone EPR1157(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417449) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for CD80 (NM_005191)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human B7-1/CD80 was used as an immunogen.
Clone NameEPR1157(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

Target NameHomo sapiens CD80 molecule (CD80)
Alternative NameB7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7
Database LinkNP_005182
FunctionThe B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with an antigen in association with MHC class II, a second signal mediated through the binding of B7-1 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signaling complexes at the T-cell surface, underscoring the importance of potent inhibitory signaling in human immune responses (2).
Related Pathway
Toll-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD80 antibody [EPR1157(2)]; All lanes : Anti-CD80 antibody [EPR1157(2)] at 1/1000 dilution.Lane 1 : Raji cell lysate.Lane 2 : Ramos cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 60 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD80 antibody [EPR1157(2)]; Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling CD80 with TA307243 at 1/100.

 

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