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Home Antibody All anti-CD59 antibodies

Anti-CD59 Antibody EPR6426

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310286
  • Rabbit Monoclonal antibody against CD59
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424608) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
FC(1)
Assay(1)
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Also for CD59 (NM_000611)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD59 was used as an immunogen.
Clone NameEPR6426 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:50000 - 1:200000; ICC: 1:250 - 1:500; IP: 1:100 - 1:500; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 2
Alternative Name16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
Database LinkNP_000602
Entrez Gene 966 Human
FunctionCD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this protein cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction (1).
Related PathwayDruggable Genome Complement and coagulation cascadesHematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD59 antibody [EPR6426]; All lanes : Anti-CD59 antibody [EPR6426] at 1/50000 dilution.Lane 1 : HUVEC cell lysate.Lane 2 : BxPC 3 cell lysate.Lane 3 : Human fetal brain lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 14 kDa.
Assay Image
Other-Anti-CD59 antibody [EPR6426](TA310286); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-CD59 antibody [EPR6426]; TA310286 at 1/10 dilution staining CD59 in permeabilized HUVEC cells by Flow cytometry (red). Rabbit IgG negative control (green).

 

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