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Home Antibody All anti-CD59 antibodies

Anti-CD59 Antibody EPR6426

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310286
  • Rabbit Monoclonal antibody against CD59
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424608) , 20ug
100ul $325 3-7 Days
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WB(1)
FC(1)
Assay(1)
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Also for CD59 (NM_000611)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD59 was used as an immunogen.
Clone NameEPR6426 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:50000 - 1:200000; ICC: 1:250 - 1:500; IP: 1:100 - 1:500; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 2
Alternative Name16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
Database LinkNP_000602
FunctionCD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this protein cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction (1).
Related Pathway
Hematopoietic cell lineage

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WB Image
Western blot - Anti-CD59 antibody [EPR6426]; All lanes : Anti-CD59 antibody [EPR6426] at 1/50000 dilution.Lane 1 : HUVEC cell lysate.Lane 2 : BxPC 3 cell lysate.Lane 3 : Human fetal brain lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 14 kDa.
Assay Image
Other-Anti-CD59 antibody [EPR6426](TA310286); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-CD59 antibody [EPR6426]; TA310286 at 1/10 dilution staining CD59 in permeabilized HUVEC cells by Flow cytometry (red). Rabbit IgG negative control (green).

 

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