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Home Antibody All anti-CD44 antibodies

Anti-CD44 Antibody EPR4773


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307654 Rabbit monoclonal antibody against CD44(clone EPR4773) 100ul $325 In Stock
LC424334 CD44 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD44 was used as an immunogen.
Clone NameEPR4773 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens CD44 molecule (Indian blood group) (CD44), transcript variant 4
Alternative NameCDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1
Database LinkNP_001001391
Entrez Gene 960 Human
Entrez Gene 12505 Mouse
FunctionCD44 is a cell-surface glycoprotein postulated to play a role in a variety of biological processes, including lymphocyte homing and tumor-cell metastasis. Several isoforms of CD44 have been identified in human cells, and the genesis of some of these isoforms has been attributed to alternative splicing. Understanding of mechanisms regulating CD44 alternative splicing may provide insights into diverse processes, including tumor-cell metastasis and lymphocyte homing (1). The deduced protein sequence of 699 amino acids has a novel 339 amino acid domain inserted into the proximal extracellular domain of the standard, leukocyte form of CD44. The additional domain adds a number of potential N- and O-linked glycosylation sites and two proteolysis sites to this form of CD44 (2). CD44 is defined as a structurally diverse, but immunologically related, set of intrinsic membrane macromolecules, and suggests that these structurally varied forms might be expected to manifest multiple functions (3).
Related PathwayStem cell relevant signaling - DSL/Notch pathwayES Cell Differentiation/IPSTransmembraneAdult stem cellsCancer stem cellsEmbryonic stem cellsDruggable Genome ECM-receptor interactionHematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD44 antibody [EPR4773]; All lanes : Anti-CD44 antibody [EPR4773] at 1/1000 dilution.Lane 1 : TF-1 cell lysate.Lane 2 : HUVEC cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 82 kDa.Observed band size : 97 kDa .


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