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Anti-CD4 Antibody EPR3155(2)
|A synthetic peptide corresponding to residues in human CD4 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:500 - 1:1000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens CD4 molecule (CD4), transcript variant 1|
|T-cell surface glycoprotein CD4 (CD4) is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is reported that CD4 regulates T-cell activation and induces the aggregation of lipid rafts. CD4 associates with LCK, binds to HIV-1 gp120 and to P4HB/PDI, and upon HIV-1 binding to the cell membrane, it is part of the P4HB/PDI-CD4-CXCR4-gp120 complex. Cell surface expression of CD4 is down-modulated by HIV-1 Envelope polyprotein gp160, which interacts with and sequesters CD4 in the endoplasmic reticulum (1).|
Hematopoietic cell lineage
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Western blot - CD4 antibody [EPR3155(2)]; All lanes : Anti-CD4 antibody [EPR3155(2)] at 1/1000 dilution.Lane 1 : Human fetal thymus lysate.Lane 2 : Human tonsil lysate.Lane 3 : PBMC lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 51 kDa.