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Anti-CD4 Antibody EPR3942
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|A synthetic peptide corresponding to residues near the N-terminus of human CD4 was used as an immunogen.|
||ICC: 1:50 - 100, WB: 1:1,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens CD4 molecule (CD4), transcript variant 1|
|T-cell surface glycoprotein CD4 (CD4) is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is said to possibly regulate T-cell activation and induce the aggregation of lipid rafts. CD4 associates with LCK, binds to HIV-1 gp120 and to P4HB/PDI, and upon HIV-1 binding to the cell membrane, it is part of the P4HB/PDI-CD4-CXCR4-gp120 complex. The subcellular location of CD4 is in the cell membrane; it is a single-pass type I membrane protein that localizes to lipid rafts. Cell surface expression of CD4 is down-modulated by HIV-1 Envelope polyprotein gp160, which interacts with and sequesters CD4 in the endoplasmic reticulum (1).|
Hematopoietic cell lineage
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Western blot analysis on (A) human tonsil, (B) fetal thymus, (C) HuT-78, and (D) Peripheral Blood Mononuclear Cell (PBMC) lysates using anti-CD4 RabMAb .