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Anti-CD4 Antibody EPR3942
|A synthetic peptide corresponding to residues near the N-terminus of human CD4 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||ICC/IF: 1:50 - 1:100; WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens CD4 molecule (CD4), transcript variant 1|
|T-cell surface glycoprotein CD4 (CD4) is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is said to possibly regulate T-cell activation and induce the aggregation of lipid rafts. CD4 associates with LCK, binds to HIV-1 gp120 and to P4HB/PDI, and upon HIV-1 binding to the cell membrane, it is part of the P4HB/PDI-CD4-CXCR4-gp120 complex. The subcellular location of CD4 is in the cell membrane; it is a single-pass type I membrane protein that localizes to lipid rafts. Cell surface expression of CD4 is down-modulated by HIV-1 Envelope polyprotein gp160, which interacts with and sequesters CD4 in the endoplasmic reticulum (1).|
Hematopoietic cell lineage
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Western blot - Anti-CD4 antibody [EPR3942]; All lanes : Anti-CD4 antibody [EPR3942] at 1/1000 dilution.Lane 1 : Human tonsil lysates.Lane 2 : Fetal thymus lysates.Lane 3 : HuT-78 lysates.Lane 4 : Peripheral Blood Mononuclear Cell (PBMC) lysates.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.