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Home Antibody All anti-CD34 antibodies

Anti-CD34 Antibody 4H11

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320263
  • Mouse Anti-Human CD34 Purified (100 ug)
100ug 120 3-7 Days
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FC(1)
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Also for CD34 (NM_001773)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen
Clone Name4H11 Isotype
Species ReactivityHuman Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *FC Suggested DilutionsFlow, Functional Assay, WB
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens CD34 molecule (CD34), transcript variant 2
Alternative NameCD34 antigen; OTTHUMP00000034733; OTTHUMP00000034734; hematopoietic progenitor cell antigen CD34; CD34 molecule
Database LinkNP_001764
FunctionThe 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.
Related Pathway
Hematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

FC Image
Staining of TF-1 cell line with 0.25 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD34 Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE . Total viable cells were used for analysis.

 

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