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Anti-CD34 Antibody 4H11
Also for CD34 (NM_001773)
||0.5-1mg/ml (lot dependent)
||Flow, Functional Assay, WB
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Homo sapiens CD34 molecule (CD34), transcript variant 2|
|CD34 antigen; OTTHUMP00000034733; OTTHUMP00000034734; hematopoietic progenitor cell antigen CD34; CD34 molecule|
Entrez Gene 947 Human
|The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.|
|ES Cell Differentiation/IPSTransmembraneAdult stem cellsCancer stem cellsEmbryonic stem cellsDruggable Genome Cell adhesion molecules (CAMs)Hematopoietic cell lineage|
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Staining of TF-1 cell line with 0.25 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human CD34 Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE . Total viable cells were used for analysis.