CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It acts as a co-receptor for the detection of bacterial lipopolysaccharide (LPS) (1). CD14 cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial LPS. It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (2). CD14 is expressed strongly on peripheral blood monocytes and macrophages, and weakly on the surface of granulocytes (1).
Hematopoietic cell lineage
MAPK signaling pathway
Toll-like receptor signaling pathway
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