Homo sapiens chemokine (C-C motif) receptor 7 (CCR7)
BLR2; CD197; CDw197; CMKBR7; EBI1
A synthetic peptide corresponding to residues in loop-3 extracellular domain of human C-C chemokine receptor type 7 was used as immunogen. The antibody does not cross-react with other CKR family members. Predicted to cross-react with pig and bovine based on sequence homology.
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
CCR7, or C-C chemokine receptor type 7, is a G protein-coupled, seven-transmembrane domain receptor protein. Originally identified as the EBV-induced gene-1 (1), CCR7 was later found to be the receptor for the chemokines CCL21 (SLC, 6Ckine, Exodus-2) (3) and CCL19 (MIP-3, Exodus-3, ELC) (4). CCR7 is expressed in lymphoid tissues and activated B and T lymphocytes (2). It is up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7 (4).
Cytokine-cytokine receptor interaction
Signaling by GPCR
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