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Anti-CCR5 Antibody E164
Also for CCR5 (NM_000579)
|A synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human CKR5 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.|
||0.5~1.0 mg/ml (Lot Dependent)
||FC: 1:20; WB: 1:2000; IHC-P: Use at an assay dependent concentration
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|IgG fraction (Protein A or G Sepharose)
|Is unsuitable for ICC or IP.
|Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A|
|CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22|
|This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
Cytokine-cytokine receptor interaction
Signaling by GPCR
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Western blot - CCR5 antibody [E164]; All lanes : Anti-CCR5 antibody [E164] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : K562 cell lysate.Lane 3 : Daudi cell lysate.Predicted band size : 41 kDa.Observed band size : 60 kDa .