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Home Antibody All anti-CCNE1 antibodies

Anti-CCNE1 Antibody EPR194

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307556
  • Rabbit monoclonal antibody against Cyclin E1(clone EPR194)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400495) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to the C-terminus of human Cyclin E1 was used as an immunogen.
Clone NameEPR194 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens cyclin E1 (CCNE1)
Alternative NameCCNE
Database LinkNP_001229
FunctionCyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4).
Related Pathway
Cell cycle
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Cyclin E antibody [EPR194]; All lanes : Anti-Cyclin E antibody [EPR194] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : JAR cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 47 kDa.

 

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