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Home Antibody All anti-CCND1 antibodies

Anti-CCND1 Antibody SP4


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307019 Rabbit monoclonal antibody against Cyclin D1(clone SP4 ) 100ul $379 In Stock
LC403284 CCND1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for CCND1 (NM_053056)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide from C-terminus of human cyclin D1.
Clone NameSP4 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100; IP: 1:20
Predicted MW Explanation 34 kDa
BufferPreservative: 0.1% Sodium azide
Constituent: 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens cyclin D1 (CCND1)
Alternative NameBCL1; D11S287E; PRAD1; U21B31
Database LinkNP_444284
Entrez Gene 595 Human
Entrez Gene 12443 Mouse
Entrez Gene 58919 Rat
FunctionThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq].
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayStem cell relevant signaling - Wnt Signaling pathwayStem cell - PluripotencyStem cell relevant signaling - DSL/Notch pathwayDruggable Genome Cell cyclep53 signaling pathwayWnt signaling pathwayFocal adhesionJak-STAT signaling pathwayPathways in cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Cyclin D1 antibody; Anti-Cyclin D1 antibody [SP4] at 1/5000 dilution + MCF7 cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 34 kDa.

WB Image
Figure from citation: Western blot analysis of CCND1 protein level by using anti-CCND1 antibody in 16HBE-T cells after transfection with siLOC728228-1. Dilution: 1:500 View Citation

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody; Immunohistochemical analysis of paraffin-embedded Human mantle cell lymphoma tissue labelling Cyclin D1 with TA307019 at 1/100.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin D1 antibody [SP4]; Immunohistochemical analysis of Human bladder tumour tissue, staining Cyclin D1 with TA307019. Antigen retrieval was performed by heat mediation in citrate buffer (pH 6), before being incubated with primary antibody (1/100). Staining was detected using DAB.


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