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Anti-CCL2 Antibody

WB(1)

Gene Name Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) Synonyms: GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF Immunogen A synthetic peptide corresponding to N-terminus of human MCP-1 was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name Isotype IgG Species Reactivity Human Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1:5,000 Background Monocyte chemoattractant protein-1 (MCP-1) is a CC chemokine that mediates/promotes monocyte recruitment into an inflammatory site and activates monocytes and macrophages. (1,2). Mainly produced by activated endothelial cells and VSMCs, MCP-1 binds to seven-transmembrane-spanning proteins (CCR2, Duffy Ag/receptor for chemokines/Duffy, D6) (3). CCR2 is the only known functional receptor for MCP-1, where MCP-1 to CCR interaction has been linked to downstream signal pathways involving heterotrimeric G protein (4). MCP-1 is involved in the pathogenesis of diseases characterized by mononuclear cell infiltration, such as rheumatoid arthritis and bronchial asthma (5). MCP-1 induced macropage infiltration in fatty tissue has been suggested as a link between obesity and insulin resistance (6). Related Pathway Cytokine-cytokine receptor interaction

Related Lysate from OriGene • Transient overexpression lysate of chemokine (C-C motif) ligand 2 (CCL2) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • CCL2 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • CCL2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Ccl12 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • CCL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Ccl12 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) as transfection-ready DNA • Lenti ORF clone of Human chemokine (C-C motif) ligand 2 (CCL2), mGFP tagged • Lenti ORF clone of Human chemokine (C-C motif) ligand 2 (CCL2) , Myc-DDK-tagged • Myc-DDK-tagged ORF clone of Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens chemokine (C-C motif) ligand 2 (CCL2) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)