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Home Antibody All anti-CBLC antibodies

Anti-CBLC TRUEMAB Antibody Clone OTI3B4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA505071 CBLC mouse monoclonal antibody, clone OTI3B4 (formerly 3B4) 100ul $379 In Stock
LC402148 CBLC HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505071 Carrier-free (BSA/glycerol-free) CBLC mouse monoclonal antibody, clone OTI3B4 (formerly 3B4) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
FC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 244-474 of human CBLC(NP_036248) produced in E.coli.
Clone NameClone OTI3B4 IsotypeIgG2b
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, FC Suggested Dilutions WB 1:500, FLOW 1:100,
Predicted MW Explanation 52.3 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC), transcript variant 1
Alternative NameCBL-3; CBL-SL; RNF57
Database LinkNP_036248
Entrez Gene 23624 Human
FunctionThis gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Related PathwayDruggable Genome ErbB signaling pathwayUbiquitin mediated proteolysisEndocytosisJak-STAT signaling pathwayT cell receptor signaling pathwayInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CBLC (RC205130, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CBLC.
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HEK293T cells transfected with either RC205130 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-CBLC antibody(TA505071), and then analyzed by flow cytometry.
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