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Anti-CBL PHOSPHO Antibody E160
|A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human Cbl was used as immunogen. The antibody detects Cbl phosphorylated on Tyrosine 774.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1,000; IHC 1:25; ICC: 1:25; IP: 1:20; FC: 1:20;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)|
|C-CBL; CBL2; FRA11B; NSLL; RNF55|
|c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4).|
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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Immunohistochemical analysis of paraffin-embedded human cervical carcinoma using TA310242 at 1/25 dilution.