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Anti-CAV2 PHOSPHO Antibody EPR2220(3)
Also for CAV2 (NM_198212)
|A phospho specific peptide corresponding to residues surrounding tyrosine 19 of human Caveolin 2. This antibody detects Caveloin 2 phosphorylated at tyrosine 19.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|WB, ASSAY, FC
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens caveolin 2 (CAV2), transcript variant 2|
|Caveolins (Caveolin 1, 2, and 3) are a family of caveolae-associated integral membrane proteins. Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking (1). Caveolin 2 is a principal component of caveolae membranes. It interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects; however, they differ in their functional interactions with heterotrimeric G proteins, possibly explaining why Caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells, which is strictly dependent on continued treatment with NGF. Both Caveolin-1 and -2 are more abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Robust expression of Caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones (1). Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3 (2).|
EGFR1 Signaling Pathway
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Western blot - Anti-Caveolin 2 (phospho Y19) antibody [EPR2220(3)]; All lanes : Anti-Caveolin 2 (phospho Y19) antibody [EPR2220(3)] at 1/1000 dilution.Lane 1 : HUVEC cell lysate untreated.Lane 2 : HUVEC cell lysate treated with Pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 18 kDa.Observed band size : 20 kDa .
Other-Anti-Caveolin 2 (phospho Y19) antibody [EPR2220(3)](ab124883); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-Caveolin 2 (phospho Y19) antibody [EPR2220(3)]; Flow cytometric analysis of permeabilized HUVEC cells, untreated (green) or pervanadate treated (red) using ab124883 at 1/10 dilution, and pervanadate-treated HUVEC cells using the same antibody preincubated with phospho-Caveolin 2 Phospho (pY19) peptide (blue) or non-phospho- Caveolin 2 Phospho (pY19) peptide (orange).