Homo sapiens caveolin 2 (CAV2), transcript variant 1
Synonyms:
CAV
Immunogen
A phospho specific peptide corresponding to residues surrounding tyrosine 27 of human Caveolin2. This antibody detects Caveloin2 phosphorylated at tyrosine 27.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins (1). Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects, however, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins (1).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
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A. Western blot analysis on HeLa cell lysates using anti-Phospho-Caveolin2 (pY27) RabMAb, 1:2000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
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