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Anti-CAV2 PHOSPHO Antibody EP2221Y
Also for CAV2 (NM_198212)
|A phospho specific peptide corresponding to residues surrounding tyrosine 27 of human Caveolin2. This antibody detects Caveloin2 phosphorylated at tyrosine 27.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1,000 - 10,000; IHC 1:100 - 250; ICC: 1:50;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens caveolin 2 (CAV2), transcript variant 2|
Entrez Gene 858 Human
|Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins (1). Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects, however, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins (1).|
|TransmembraneDruggable Genome Focal adhesion|
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Western blot - Caveolin 2 (phospho Y27) antibody [EP2221Y]; All lanes : Anti-Caveolin 2 (phospho Y27) antibody [EP2221Y] at 1/2000 dilution.Lane 1 : HeLa cell lysates untreated.Lane 2 : HeLa cell lysates treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 18 kDa.Observed band size : 20 kDa .