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Anti-CAV1 PHOSPHO Antibody EPR2288Y
Also for CAV1 (NM_001753)
|A phospho specifici peptide corresponding to residues surrounding tyrosine 14 of human caveolin-1 was used as an immunogen. This antibody detects caveolin-1 phosphorylated at tyrosine 14.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2000 - 1:5000; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1), transcript variant 1|
|BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21|
Entrez Gene 857 Human
|Caveolins make up a family of proteins that are principal structural components of hairpin-like domains in the plasma membrane (1). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Three members of caveolins (caveolin-1, -2 and -3) have been identified, possessing different tissue distributions (2). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit (1), tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS (2,3). Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia (4). Endothelial cell (EC) migration is a critical event during multiple physiological and pathological processes. The phosphorylatable Tyr14 residue of caveolin-1 is required for polarization of the protein during transmigration but does not alter polarization during planar movement. |
|TransmembraneDruggable Genome Focal adhesionViral myocarditis|
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Western blot - Caveolin 1 (phospho Y14) antibody [EPR2288Y]; All lanes : Anti-Caveolin 1 (phospho Y14) [EPR2288Y] antibody at 1/2000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 20 kDa.Observed band size : 22 kDa .