Home Antibody All anti-CASP8 antibodies
Also for CASP8 (NM_001080124)
|Caspase-8 antibody was raised against a 15 amino acid peptide from near the carboxy terminus human caspase-8 isoform E.|
||WB: 0.5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant F|
|ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5|
Entrez Gene 841 Human
Entrez Gene 12370 Mouse
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex (4). The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation (reviewed in 5). FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis (6). This antibody will only detect isoform E of caspase-8.|
|ProteaseDruggable Genome p53 signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseaseMore Pathways >> |
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Western blot analysis of Caspase-8 in HT-29 cell lysate with Caspase-8 antibody (IN) at 1 µg/ml in (A) the presence or (B) the absence of blocking peptide.