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Anti-CASP8 Antibody E6


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CASP8 (Clone E6)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403245) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to N-terminal residues of human Caspase-8 was used as immunogen. The antibody should recognize all splice isoforms of Caspase-8.
Clone NameE6 IsotypeIgG fraction
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:3000; IHC-P: Use at an assay dependent dilution; FC: 1:50; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant B
Alternative NameALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Database LinkNP_203519
Entrez Gene 841 Human
FunctionCaspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death (1-4). Caspase-8 is recruited to death-inducing signaling complex (DISC) CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18 (1-4). Active caspase-8, the first in the caspase signaling cascade, signals downstream caspases to eventually induce apoptosis.
Related PathwayProteaseDruggable Genome p53 signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseaseMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Caspase 8 antibody [E6]; Anti-Caspase 8 antibody [E6] at 1/3000 dilution + Jurkat cell lysate.Predicted band size : 55 kDa.Observed band size : 55 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Caspase 8 antibody [E6]; Immunohistochemical analysis of Caspase 8 expression in paraffin embedded human breast adenocarcinoma tissue section using 1/100 TA300332.


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