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Home Antibody All anti-CASP6 antibodies

Anti-CASP6 Antibody EPR4405

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307560
  • Rabbit monoclonal antibody against Caspase-6(clone EPR4405)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400490) , 20ug
100ul 325 3-7 Days
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WB(1)
FC(1)
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Also for CASP6 (NM_001226)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenA synthetic peptide corresponding to the C-terminus of p18 subunit of human Caspase-6 was used as an immunogen.
Clone NameEPR4405 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha
Alternative NameMCH2
Database LinkNP_001217
FunctionCaspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves many different intracellular proteins, including nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).
Related Pathway
Apoptosis
MAPK signaling pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caspase 6 antibody [EPR4405]; All lanes : Anti-Caspase 6 antibody [EPR4405] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Jurkat + staurosporine cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 33 kDa.
FC Image
Flow Cytometry - Caspase 6 antibody [EPR4405]; TA307560, at 1/10 dilution, staining Caspase 6 in permeabilized Jurkat cells by Flow cytometry (shown in red). Rabbit IgG shown in green (negative).

 

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