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Anti-CASP6 Antibody E180
Also for CASP6 (NM_001226)
|A synthetic peptide corresponding to residues in C-terminus of human Caspase-6 was used as immunogen. The antibody should recognize both pro-form and p11 subunit.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100; FC: 1:30
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for IP.
|Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha|
|Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).|
MAPK signaling pathway
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Western blot - Caspase 6 antibody [E180]; All lanes : Anti-Caspase 6 antibody [E180] at 1/1000 dilution.Lane 1 : Untreated Jurkat cell lysate. .Lane 2 : Jurkat cell lysate treated with Camptothecin. .Predicted band size : 34 kDa.Observed band size : 30 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Caspase 6 antibody [E180]; Ab32366, at a 1/50 dilution, staining Caspase 6 in paraffin embedded human lung adenocarcinoma tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - Caspase 6 antibody [E180]; Ab32366, at a 1/100 dilution, staining Caspase 6 in Hela cells by Immunocytochemistry/Immunofluorescence.