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Home Antibody All anti-CASP4 antibodies

Anti-CASP4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306195
  • Rabbit Polyclonal Caspase-4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400489) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for CASP4 (NM_001225)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCaspase-4 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha
Alternative NameICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX
Database LinkNP_001216
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).
Related Pathway
Apoptosis

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WB Image
Western blot analysis of caspase-4 in Ramos cells with caspase-4 antibody at (A) 0.5 and (B) 1 ugg/ml.</title><style>.an6q{position:absolute;clip:rect(487px,auto,auto,487px);}</style><div class=an6q>According to your current <a href=http://paydayloansforsure.com >need cash now</a> you really look at.</div>
IHC Image
Immunohistochemical staining of mouse spleen using caspase-4 antibody at 2 ug/ml.</title><style>.an6q{position:absolute;clip:rect(487px,auto,auto,487px);}</style><div class=an6q>According to your current <a href=http://paydayloansforsure.com >need cash now</a> you really look at.</div>

 

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