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Home Antibody All anti-CASP3 antibodies

Anti-CASP3 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319624 Rabbit Polyclonal Caspase-3 Antibody 100ug $325 3-7 Days
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Also for CASP3 (NM_004346)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Assay

OriGene Data

ImmunogenCaspase-3 antibody was raised against a 17 amino acid synthetic peptide near the center of human Caspase-3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsIHC: 5 ug/mL
Predicted MW Explanation 30 kDa
BufferCaspase-3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification Caspase-3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha
Alternative NameCPP32; CPP32B; SCA-1
Database LinkNP_004337
Entrez Gene 836 Human
FunctionCaspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.
Related PathwayES Cell Differentiation/IPSProteaseDruggable Genome MAPK signaling pathwayp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicityAlzheimer's diseaseParkinson's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry of Caspase-3 in human tonsil tissue with Caspase-3 antibody at 5 ug/mL.


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