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Home Antibody All anti-CASP3 antibodies

Anti-CASP3 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319624
  • Rabbit Polyclonal Caspase-3 Antibody
100ug $325 3-7 Days
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IHC(1)
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Also for CASP3 (NM_004346)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenCaspase-3 antibody was raised against a 17 amino acid synthetic peptide near the center of human Caspase-3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsELISA, IHC: 5 ug/ml
BufferCaspase-3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification Caspase-3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant alpha
Alternative NameCPP32; CPP32B; SCA-1
Database LinkNP_004337
FunctionCaspase-3 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.
Related Pathway
Apoptosis
MAPK signaling pathway

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IHC Image
Immunohistochemistry of Caspase-3 in human tonsil tissue with Caspase-3 antibody at 5 ug/mL.

 

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