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Home Antibody All anti-CASP3 antibodies

Anti-CASP3 Antibody CPP32 4-1-18

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Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301776 Mouse Monoclonal Antibody against Caspase 3 (CPP32 4-1-18) 200ul $325 In Stock
LC403215 CASP3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
IHC(1)
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Also for CASP3 (NM_032991)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Assay

OriGene Data

ImmunogenFull-length recombinant human Caspase 3 protein.
Clone NameCPP32 4-1-18 IsotypeIgG2a kappa
Species Reactivityhuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1: 1000
Buffer0.1% sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant beta
Alternative NameCPP32; CPP32B; SCA-1
Database LinkNP_116786
Entrez Gene 836 Human
FunctionCaspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Related PathwayES Cell Differentiation/IPSProteaseDruggable Genome MAPK signaling pathwayp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicityAlzheimer's diseaseParkinson's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot detection of Capsase (19 and 35 kDa) from HEK293 cell extract. Lanes 1 and 2 contain inactive and active Capsase, respectively
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Figure from citation: Western Blot of CASP3 protein level by using anti-CASP3 antibody in human MCF7 and its sub-lines (TamR7 and TamC3) and MDA-MB 231 cells. View Citation
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Immunohistochemistry-Paraffin: Caspase 3 Antibody (CPP32 4-1-18) - Rat epithelial cells of the tongue base. Antigen retrieval method: Citrate buffer.
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