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Anti-CASP2 Antibody Y61
Also for CASP2 (NM_032982)
|A synthetic peptide corresponding to N-terminus of human Caspase-2 p15 subunit was used as immunogen. The antibody should recognize both pro-form (~50kDa) and p15 cleaved-form of Caspase-2.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500; FC: 1:10
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Does not react with Rat
|Homo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 1|
|CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57|
|This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq]. |
MAPK signaling pathway
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Western blot - Caspase 2 antibody [Y61]; All lanes : Anti-Caspase 2 antibody [Y61] at 1/500 dilution.Lane 1 : Jurkat cell lysate - untreated.Lane 2 : Jurkat cell lysate - treated with Camptothecin.Predicted band size : 49 kDa.Observed band size : 48 kDa .Additional bands at : 15 kDa (possible cleavage fragment).