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Home Antibody All anti-CASP1 antibodies

Anti-CASP1 Antibody EPR456

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307025
  • Rabbit monoclonal antibody against Caspase-1(clone EPR456)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409611) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for CASP1 (NM_033292)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Caspase-1 was used as an immunogen.
Clone NameEPR456 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 45 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant alpha
Alternative NameICE; IL1BC; P45
Database LinkNP_150634
Entrez Gene 834 Human
Entrez Gene 12362 Mouse
Entrez Gene 25166 Rat
FunctionCaspase-1 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, p20 and p10, that dimerize to form the active enzyme. Caspase-1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in processes such as inflammation, septic shock, and wound healing. Caspase-1 has been shown to induce cell apoptosis and may function in various developmental stages (1).
Related PathwayProteaseDruggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caspase 1 antibody [EPR456]; All lanes : Anti-Caspase 1 antibody [EPR456] at 1/1000 dilution.Lane 1 : Human Fetal brain lysate.Lane 2 : THP1 lysate.Lane 3 : Jurkat lysate.Lane 4 : HL60 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 45 kDa.

 

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