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Anti-CASP1 Antibody EPR456
Also for CASP1 (NM_033292)
|A synthetic peptide corresponding to residues in human Caspase-1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant alpha|
|ICE; IL1BC; P45|
|Caspase-1 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, p20 and p10, that dimerize to form the active enzyme. Caspase-1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in processes such as inflammation, septic shock, and wound healing. Caspase-1 has been shown to induce cell apoptosis and may function in various developmental stages (1).|
MAPK signaling pathway
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Western blot - Caspase 1 antibody [EPR456]; All lanes : Anti-Caspase 1 antibody [EPR456] at 1/1000 dilution.Lane 1 : Human Fetal brain lysate.Lane 2 : THP1 lysate.Lane 3 : Jurkat lysate.Lane 4 : HL60 lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 45 kDa.