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Anti-CASP1 Antibody EPR4321
Also for CASP1 (NM_033292)
|A recombinant protein fragment corresponding to amino acids 253-404 of human Caspase-1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant alpha|
|ICE; IL1BC; P45|
Entrez Gene 834 Human
Entrez Gene 12362 Mouse
Entrez Gene 25166 Rat
|Caspase-1 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, p20 and p10, that dimerize to form the active enzyme. This protein was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. Caspase-1 has been shown to induce cell apoptosis and may function in various developmental stages (1).|
|ProteaseDruggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayAmyotrophic lateral sclerosis (ALS)|
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Western blot - Caspase 1 antibody [EPR4321]; All lanes : Anti-Caspase 1 antibody [EPR4321] at 1/1000 dilution.Lane 1 : THP-1 cell lysates.Lane 2 : THP-1+TPA+LPS cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : C6 cell lysate .Lane 5 : NIH/3T3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 45 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Caspase 1 antibody [EPR4321]; TA307024, at 1/250, staining Caspase 1 in paraffin-embedded Human breast invasive ductal carcinoma tissue by Immunohistochemistry.