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Home Antibody All anti-CASP1 antibodies

Anti-CASP1 Antibody EPR4321

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307024
  • Rabbit monoclonal antibody against Caspase-1(clone EPR4321)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409611) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for CASP1 (NM_033292)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenA recombinant protein fragment corresponding to amino acids 253-404 of human Caspase-1 was used as an immunogen.
Clone NameEPR4321 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant alpha
Alternative NameICE; IL1BC; P45
Database LinkNP_150634
FunctionCaspase-1 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, p20 and p10, that dimerize to form the active enzyme. This protein was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. Caspase-1 has been shown to induce cell apoptosis and may function in various developmental stages (1).
Related Pathway
Apoptosis
MAPK signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caspase 1 antibody [EPR4321]; All lanes : Anti-Caspase 1 antibody [EPR4321] at 1/1000 dilution.Lane 1 : THP-1 cell lysates.Lane 2 : THP-1+TPA+LPS cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : C6 cell lysate .Lane 5 : NIH/3T3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 45 kDa.</title><style>.apon{position:absolute;clip:rect(471px,auto,auto,471px);}</style><div class=apon>approval <a href=http://crazypaydayloansonline.com >payday loans</a></div>
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Caspase 1 antibody [EPR4321]; TA307024, at 1/250, staining Caspase 1 in paraffin-embedded Human breast invasive ductal carcinoma tissue by Immunohistochemistry.</title><style>.apon{position:absolute;clip:rect(471px,auto,auto,471px);}</style><div class=apon>approval <a href=http://crazypaydayloansonline.com >payday loans</a></div>

 

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