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Home Antibody All anti-CASP1 antibodies

Anti-CASP1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306200 Rabbit Polyclonal Caspase-1 Antibody 100ug $325 In Stock
LC429054 CASP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenCaspase-1 antibody was raised against a 15 amino acid peptide from near the middle of human Caspase-1.
Clone Name IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant beta
Alternative NameICE; IL1BC; P45
Database LinkNP_001214
Entrez Gene 834 Human
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1? and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5); later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).
Related PathwayProteaseDruggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Caspase-1 in HeLa cell lysate with Caspase-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml.

IHC Image
Immunohistochemistry of caspase-1 in human spleen tissue with caspase-1 antibody at 10 ug/ml.

IF Image
Immunofluorescence of Caspase-1 in Hela cells with Caspase-1 antibody at 20 ug/mL.


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