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Home Antibody All anti-CASP1 antibodies

Anti-CASP1 Antibody

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SKU Description Amount Price Availability*  
TA306199
  • Rabbit Polyclonal Caspase-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC429054) , 20ug Explanation
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenCaspase-1 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant beta
Alternative NameICE; IL1BC; P45
Database LinkNP_001214
Entrez Gene 834 Human
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1? and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5); later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).
Related PathwayProteaseDruggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Caspase-1 in human heart cell lysate with Caspase-1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
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Immunohistochemical staining of human heart tissue using Caspase-1 antibody at 2 ug/ml.
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