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Anti-CARD11 Antibody EPR3177
Also for CARD11 (NM_032415)
|A synthetic peptide corresponding to residues on the C-terminus in human CARD11 was used as an immunogen.|
||Tissue culture supernatant
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
|Does not react with Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens caspase recruitment domain family, member 11 (CARD11)|
|BENTA; BIMP3; CARMA1; IMD11; PPBL|
Entrez Gene 84433 Human
Entrez Gene 108723 Mouse
|CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. It is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). CARD11 has a domain structure similar to that of CARD14. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, CARD11 activated NF-kappaB and induced the phosphorylation of BCL10.|
|Druggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway|
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Western blot - CARD11 antibody [EPR3177]; All lanes : Anti-CARD11 antibody [EPR3177] at 1/1000 dilution.Lane 1 : K562 cell lysates .Lane 2 : Ramos cell lysates .Lysates/proteins at 10 ug per lane.Predicted band size : 133 kDa.Observed band size : 130 kDa .