Home Antibody All anti-CARD11 antibodies
Also for CARD11 (NM_032415)
|CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase recruitment domain family, member 11 (CARD11)|
|BENTA; BIMP3; CARMA1; IMD11; PPBL|
Entrez Gene 84433 Human
Entrez Gene 108723 Mouse
|CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).|
|Druggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of CARMA1 expression in mouse thymus cell lysate with CARMA1 antibody at 0.5 (lane A), 1 (lane B), and 2 ug /ml (lane C), respectively.
Immunohistochemistry of CARMA1 in mouse thymus with CARMA1 antibody at 10 ug/ml.