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Home Antibody All anti-CA9 antibodies

Anti-CA9 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA301431 Rabbit Polyclonal Antibody against Carbonic Anhydrase IX 100ul $325 3-7 Days
LC400485 CA9 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide derived from a C-terminal sequence of the human CA IX.
Clone Name IsotypeIgG
Species Reactivityhuman, dog Concentration1.1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1000, IHC: 1: 1000, IF: 1: 1000
BufferTris-citrate/phosphate, pH 7-8, 0.1% sodium Azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens carbonic anhydrase IX (CA9)
Alternative NameCAIX; MN
Database LinkNP_001207
Entrez Gene 768 Human
Entrez Gene 611933 Dog
FunctionCarbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and the location of the expressed protein within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
Related PathwayTransmembraneDruggable Genome Nitrogen metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western Blot: Carbonic Anhydrase IX Antibody - Analysis of CAIX on rat renal cortex using TA301431
Immunohistochemistry-Frozen: Carbonic Anhydrase IX Antibody - Analysis of human colon carcinoma, xenografted in mice. Image courtesy of an anonymous product review.
Immunocytochemistry/Immunofluorescence: Immunofluorescence of human RCC tumor cryosections using TA301431 (Panel A). Panel B shows staining with normal rabbit serum.


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