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Home Antibody All anti-Bst2 antibodies

Anti-Bst2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306600
  • Rabbit Polyclonal Bst2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401380) , 20ug Explanation
100ug 325 In Stock
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WB(1)
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Also for Bst2 (NM_004335)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBst2 antibody was raised against a 18 amino acid peptide near the amino terminus of the mouse Bst2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens bone marrow stromal cell antigen 2 (BST2)
Alternative NameCD317; TETHERIN
Database LinkNP_004326
Entrez Gene 684 Human
Entrez Gene 69550 Mouse
FunctionBst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bst2 in Daudi cell lysate with Bst2 antibody at (A) 1 and (B) 2 µg/ml.

 

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