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Also for Birc5 (NM_009689)
|Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Mus musculus baculoviral IAP repeat-containing 5 (Birc5), transcript variant 1|
|AAC-11; Api4; survivin40; TIAP|
|Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).|
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Western blot analysis of survivin in mouse spleen tissue lysate with survivin antibody at 1 ug/ml.
Immunohistochemistry of Survivin in mouse spleen cells with Survivin antibody at 10 ug/ml.