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Home Antibody All anti-BUB3 antibodies

Anti-BUB3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306431
  • Rabbit Polyclonal Bub3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400384) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for BUB3 (NM_001007793)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBub3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human bub3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BUB3 mitotic checkpoint protein (BUB3), transcript variant 2
Alternative NameBUB3L; hBUB3
Database LinkNP_001007794
Entrez Gene 9184 Human
Entrez Gene 12237 Mouse
FunctionThe mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
Related PathwayDruggable Genome Cell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of bub3 in Jurkat cell lysate with bub3 antibody at (A) 0.5 and (B) 1 ug/mL.
IF Image
Immunocytochemistry of Bub3 in Jurkat cells with Bub3 antibody at 10 ug/mL.

 

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