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Anti-BUB1B Antibody 8G1
Also for BUB1B (NM_001211)
|A portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1-350 of human BUBR1).|
||Lot dependent; please refer to CoA along with shipment
|protein G purified
|Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B)|
|Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1|
Entrez Gene 701 Human
Entrez Gene 12236 Mouse
|Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.|
|Protein KinaseStem cell - PluripotencyDruggable Genome Cell cycle|
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BUBR1 detected in HeLa cell lysate
Immunofluorescence of an asynchronous cycling population of human cells (U2OS). No signal is detected from interphase cells, whereas cells undergoing mitosis accumulate BubR1 at the kinetochores. Image reveals kinetochores at prometaphase.