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Home Antibody All anti-BUB1B antibodies

Anti-BUB1B Antibody 8G1

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301741
  • Mouse Monoclonal Antibody against BUBR1 (8G1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420068) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IF(1)
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Also for BUB1B (NM_001211)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA portion of hBUBR1 tagged at the N-terminus with pMAL (residues 1-350 of human BUBR1).
Clone Name8G1 IsotypeIgG1 kappa
Species Reactivityhuman, mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:2000-1:5000
Predicted MW Explanation 119.4 kDa
Buffer
Purification protein G purified

Reference Data

Target NameHomo sapiens BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B)
Alternative NameBub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1
Database LinkNP_001202
Entrez Gene 701 Human
Entrez Gene 12236 Mouse
FunctionCompromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Related PathwayProtein KinaseStem cell - PluripotencyDruggable Genome Cell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
BUBR1 detected in HeLa cell lysate
IF Image
Immunofluorescence of an asynchronous cycling population of human cells (U2OS). No signal is detected from interphase cells, whereas cells undergoing mitosis accumulate BubR1 at the kinetochores. Image reveals kinetochores at prometaphase.

 

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