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Anti-BTK TRUEMAB Antibody Clone OTI12H4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA501091 anti-BTK mouse monoclonal antibody, clone OTI12H4 (formerly 12H4) 100ul 325
In Stock
LC424947 BTK HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501091 Carrier-free (BSA/glycerol-free) BTK mouse monoclonal antibody, clone OTI12H4 (formerly 12H4) 100ug $450 3-4 weeks
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OriGene Data

ImmunogenFull length human recombinant protein of human BTK (NP_000052) produced in HEK293T cell.
Clone NameClone OTI12H4 IsotypeIgG3
Species ReactivityHuman Concentration0.92 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB 1:500, IHC 1:50, IF 1:100, Flow 1:100
Predicted MW Explanation 76.1kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), transcript variant 1
Alternative NameAGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Database LinkNP_000052
Entrez Gene 695 Human
FunctionThe protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes,and associated with a failure of Ig heavy chain rearrangement.
Related PathwayProtein KinaseDruggable Genome B cell receptor signaling pathwayFc epsilon RI signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTK (RC211582, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTK.
Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-BTK mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501091, Dilution 1:50)
Anti-BTK mouse monoclonal antibody (TA501091) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BTK(RC211582).
HEK293T cells transfected with either pCMV6-ENTRY BTK(RC211582)(Red) or empty vector control plasmid(Blue) were immunostained with anti-BTK mouse monoclonal(TA501091), and then analyzed by flow cytometry.
Flow cytometric Analysis of Jurkat cells, using anti-BTK antibody(TA501091),(Red), compared to a nonspecific negative control antibody,(Blue).


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